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Image Search Results
Journal: Biophysical Reviews
Article Title: The ribosome’s energy landscape: Recent insights from computation
doi: 10.1007/s12551-014-0155-1
Figure Lengend Snippet: Local fluctuations are consistent between highly detailed and simplified models. A) Spatial RMSF of the 16S rRNA calculated from a 250-ns explicit-solvent simulation (> 3 × 106 atoms) and an all-atom structure-based SMOG model (≈150,000 atoms) (Whitford et al. 2010a). While the SMOG model uses a simplified description of the energetics, the local fluctuations are consistent in scale and distribution. B) The first principal component (PC) calculated from a simulation with an all-atom SMOG model (simulation described in Noel et al. (2014) is shown, where the arrows indicate the direction and scale of movement of each P atom in the small subunit (cyan). The first PC captures rotation of the small subunit, consistent with NMA and PCA results with coarse-grained models (Trylska et al. 2005; Tama et al. 2003), demonstrating that local fluctuations are not strongly influenced by energetic details. For reference, the 23S rRNA is shown in transparent representation in the background
Article Snippet: Abbreviations tRNA transfer RNA aa-tRNA aminoacyl-transfer RNA EF-Tu Elongation Factor Tu EF-G Elongation Factor G SMOG Structure-based models in
Techniques: Solvent